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The body needs specific nutrients to create the DAO enzyme that clears histamine.

copper dao histamine vitamin b6 vitamin c

So many people struggle with histamine intolerance, and I really feel for them. But I also genuinely believe that “histamine intolerance” is a bit of a misnomer. “Histamine buildup” is more like it.
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Histamines are compounds in food and the body, stored in mast cells in almost all tissues. They’re also involved in making stomach acid, muscle contraction and more. When we encounter an allergen, they’re released in our skin, mouth, nose, gut and blood, and move to the affected area. Histamines dock at receptors there and make us create mucus, sneeze, cough and itch.
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Let’s make this clear: they’re a natural and important part of our physiology.
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To clear histamine, our body naturally makes an enzyme called Diamine Oxidase (DAO) aka Histaminase. But to make that enzyme, Vitamin B6, Vitamin Ⓒ and — you guessed it — Copper are required. Many people are deficient in these nutrients.
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In fact, Ceruloplasmin, a critical copper protein complex, increases histamine clearance by 400X. “...the result was a 400-fold increase in histaminolytic activity.” (Holmberg & Laurell)
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What about antihistamines? These can definitely provide relief and do so by blocking histamine receptors. But if we’re not addressing the root cause of our histamine issues, it’s likely we may always have histamine issues.
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Where to go from here?
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〰️Read my post on estrogen and histamine (“Allergies” highlight), which can potentiate issues.
〰️Read my post on Vitamin B6 (“Morning Sickness” highlight), which is required to create the DAO enzyme.
〰️Read my post on Copper-rich foods (“Iron & Copper” highlight), which is required to create the DAO enzyme.
〰️Read my posts on real Vitamin Ⓒ (“Minimize” highlight), which is required to create the DAO enzyme.
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Absolutely not medical advice. Always consult your healthcare provider.

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This is not medical advice. Always consult your healthcare professional before pursuing any changes to your personal healthcare regime.

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References

Holmberg, C.G. Laurell, C.B. (1948). Histaminolytic Activity of a Copper Protein in Serum. Retrieved from: https://pubmed.ncbi.nlm.nih.gov/18867687/.

Karlin, K.D. Nanthakumar, A. Fox, S. Murthy, N. (1995). Copper-dioxygen chemistry and modeling the Fe-Cu center in cytochrome c oxidase. Retrieved from: https://www.researchgate.net/publication/239270495_Copper-dioxygen_chemistry_and_modeling_the_Fe-Cu_center_in_cytochrome_c_oxidase.

Living Well Dallas. HISTAMINE AND YOUR THYROID. Retrieved from: https://www.livingwelldallas.com/functional-medicine/histamine-and-your-thyroid/.

MTHFR Support. Retrieved from: https://mthfrsupport.com.au/2016/09/dao-deficiency-and-histamine-the-unlikely-connection/.

Murrell, D. (2019). What is histamine intolerance?. Retrieved from: https://www.healthline.com/health/histamine-intolerance.

Nambardekar, N. (2020). What Are Histamines?. Retrieved from: https://www.webmd.com/allergies/what-are-histamines.

Robbins, M. (2016). Iron Toxicity Post #29: Irregular iron blood markers, especially low ferritin is code for more magnesium, ceruloplasmin and B2. Retrieved from: https://therootcauseprotocol.com/mag-pie-alert-30-toxicity-of-iron/.

Schultz, R. (2020). Your Mystery Food Sensitivity Might Actually Be a Histamine Intolerance. Retrieved from: https://www.entandallergy.com/blog-posts/details/your-mystery-food-sensitivity-might-actually-be-a-histamine-intolerance#:~:text=What%20are%20the%20symptoms%20of,%2C%20headaches%2C%20or%20asthma%20attacks.

The Nature Doctor. (2017). Iodine & Histamine? (what you likely have and do not know...). Retrieved from: https://www.youtube.com/watch?v=seymLq1ofXA.

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Remember: this post is for informational purposes only and may not be the best fit for you and your personal situation. It shall not be construed as medical advice. The information and education provided here is not intended or implied to supplement or replace professional medical treatment, advice, and/or diagnosis. Always check with your own physician or medical professional before trying or implementing any information read here. While the owner of this website tries to keep the information up to date, there may be things that are out-of-date and out of their control.